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KMID : 0380620080400030316
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Korean Journal of Food Science and Technology
2008 Volume.40 No. 3 p.316 ~ p.320
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Engineering/Processing/Sensory Evaluation : Phytoestrogenic Effects of Combined Plant Extracts on the Change of Bone Metabolism of OVX Rats
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Kim Soo-Nam
Lee Yong-Chun
Seo Hong-Duk
Lee Dong-Geun
Kim Min-Seop
Lee Sung-Pyo
Lee Kwon-Taek
Lee Jae-Kyung
Kim Jae-Soo
Kwon Myung-Sang
Chang Pahn-Shick
Kwak Bo-Yeon
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Abstract
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This study examined the combined plant extracts (FGF271) of Estromon in ovariectomized (OVX) rats to determine whether Estromon`s significant clinical improvement effects on menopausal symptoms are predominantly due to the phytoestrogenic action of the combined extracts. The results showed that all three FGF271-treated groups had significantly improved serum osteocalcin levels as compared to the control group (p<0.05). In addition, all FGF271- and Estromon-treated groups had increases in femoral bone mineral density (FBMD) (p<0.05), and the increase in the FGF271 group was dose-dependent. A pairwise comparison of the FGF271- and Estromon-treated groups receiving the same dosage of FGF271 indicated that there was no significant difference between the groups. Therefore, the FBMD increases that occurred in the Estromon groups were solely attributable to the phytoestrogenic effects of FGF271. It was conclude that the phytoestrogenic effects of Estromon, as shown in clinical studies, are predominantly caused by FGF271, the mixed extracts of Cynanchum wilfordii, Phlomis umbrosa, and Angelica gigas.
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KEYWORD
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Estromon, FGF271, Cynanchum wilfordii, Phlomis umbrosa, Angelica gigas
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